Health and researchscience

Mixing alcohol and cannabis - what does it do to us?

Studies have shown that consuming alcohol in combination with cannabis, even in small amounts, significantly increases the concentration of THC in the blood and, consequently, also its level of psychoactive effect.

Consuming small amounts of alcohol (as 2 drinks) together with cannabis significantly increases blood THC levels, according to an experimental study published in the Journal of the American Association for Clinical Chemistry.

Contrast To previous studies In a field that examined a combination of high doses of alcohol with cannabis, the present study examined the effects of combination cannabis with dosing low Of alcohol, which is considered to be 2 beverages.

The study was conducted by researchers from the University of Baltimore and Iowa State University's Faculty of Medicine, in conjunction with the National Institute for Drug Abuse Research in the United States, which provided cannabis for the study.

The study 32 tested cannabis consumers who smoke on average once a week and most of them consumed cannabis in the week before the experiment, in a multivariate study with 6 in different experimental conditions:

1 - consumed a placebo of alcohol (fruit juice whose glass rim was wiped with a cloth with ethanol to simulate the taste and smell of alcohol), and 10 minutes afterwards consumed evaporation of 500 mg of cannabis placebo (Cannabis Hemp, almost without THC or CBD) .

2 conditions consumed a placebo of alcohol and 10 minutes followed by evaporation of 500 mg of weak Cannabis (2.9% THC).

3 conditions consumed a placebo of alcohol and 10 for 1 min and then consumed 500 mg of stronger cenabis (6.7% THC).

4 Conditions - Use a low dose of alcohol adjusted to their body weight to reach an alcohol level of approximately 0.065% (between 2 and 2.5 drinks, depending on weight). 10 minutes were then consumed with evaporation of 500 mg of cannabis placebo (HEMP).

5 - Use a low-dose alcohol that is adjusted to weight to reach a concentration of 0.065% in the blood. 10 minutes were then consumed with evaporation of 500 mg of weak cannabis (2.9% THC).

6 conditions consumed a low dose of alcohol, and 10 minutes were followed by evaporation of 500 mg of stronger cannabis (6.7% THC).

In contrast to interdisciplinary research in which subjects are divided into different groups according to the different experimental conditions, in this case it is an intra-experiential study, meaning that each participant participated in each of the experimental conditions with a break of at least one week between condition and condition.

The advantage of such research is that it negates interpersonal differences between the subjects as an alternative explanation of the results, since the comparison is conducted within the same group of subjects.

Blood and plasma samples of subjects were taken prior to consumption and multiple times during 8 hours following consumption.

Results

The results clearly show that low alcohol intake with cannabis significantly increases the concentration of THC in the blood, and this increase is higher when cannabis is stronger.

A maximum level of THC in the blood, without alcohol or with little alcohol (about 2 drinks)
A maximum level of THC in the blood, without alcohol or with little alcohol (about 2 drinks)

19 subjects successfully completed the trial and participated in each of the six study conditions. 1,324 blood samples and 1,327 plasma samples of the subjects were analyzed during the study.

The authors suggest that these results may explain the findings Studies Former US Department of Transportation researchers found that the driving injury resulting from a combination of cannabis and alcohol is far more severe than cannabis alone, and slightly more severe than alcohol alone.


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