The endocannabinoid system is a central internal system that affects a very wide range of biological and chemical processes in the body and is a crucial factor in the health and proper functioning of the systems in the body. The system consists of molecules called cannabinoids. When they are found in cannabis, they are called cannabinoids and when they are in the body they are called endocannabinoids, as well as cannabinoid receptors that interact with the components when they come from outside sources. And what does all this have to do with 'homeostasis' - the body's ability to maintain balance.
So far only about a hundred, perhaps a little more, Cannabinoids In the cannabis plant, the most famous of which is of course THC, and in recent years gets a place of honor also CBD (cannabidiol). The CBD, a non-psychoactive substance similar to that of THC, is expected to dominate the pharmaceutical world in the coming years and many companies are now investing in the development of CBD and its products. There is also a long list of cannabinoids, such as CBG, CBL, CBN, and more.
Endocannabinoid system - cannabis in the human body
The human body also produces its own cannabinoids, called endocannabinoids, which form part of the body The endocannabinoid system. These endogenous cannabinoids (endocannabinoids) Endogeny - procedures that occur within an organism) contain the element 'anandamide' as well as the AG-2 component. These components are in the body of each and every one of us.
The name 'Anandamid' was given to the same component by Professor ' Rafael Meshulam, The award-winning Israeli researcher who first identified the THC in the 60 of the last century. Meshulam chose to call the component "Anandamid" after the word "Ananda", which is derived from the Sanskrit language and means "supreme bliss." The full story about the endocannabinoid system and how it was discovered by Prof. Meshulam You can read in an interview with him. Recently, the documentary film "The scientist"About the extensive career of" the grandfather of cannabis ".
The endocannabinoid system also contains cannabinoid receptors of two types: CB1 and CB2. These receptors in the human body interact with cannabinoids. For years, it was known that these receptors were found in different parts of the body, in the spine and in the immune system - but mainly in the brain. They have a very vital effect on normal functioning of the systems by communicating with those cannabinoids (cannabis) and endocannabinoids (from the body). When the cannabinoids communicate to the receptors, they affect the functioning of the systems in the body.
While cannabinoid receptors are mainly found in the brain and immune system, Researchers have discovered in recent years The same receptors in other parts of the body, including the nervous system, the cardiovascular system, the reproductive system, the digestive system and the bladder. Researchers are continuing studies to identify and discover additional cannabinoids as the study of cannabis develops worldwide.
The importance of the system
The endocannabinoid system is not unique and exclusive to the human body, of course. In fact, endocannabinoids can be found in the bodies of all mammals - and even in some non-mammalian animals - indicating their vitality for the natural development of organisms in nature and the entire process of evolution.
Researchers believe that evolution, the process of genetic change in the population of organisms over generations that may lead to the creation of new species, has kept the endocannabinoid system intact over 500 for a million years.
While the endocrine system affects a wide range of biological processes, such as appetite, fatigue, and sleep, researchers believe that its main purpose is to "Homeostasis(Homeostasis) - the ability of a biological creature to maintain a stable internal environment despite changes in the external environment. This is the name of the roof of a complex of biological processes, thanks to which a living body maintains the stability of its internal environment even when changes occur in its external environment, and when it does not function properly, diseases are created.
Illness is actually the result of the body's failure to reach homeostasis, which explains again the The importance of the endocannabinoid system Health and proper functioning of the body and soul. Sigmund Freud argued that man aspires to reach a balance of mind and thus, actually reach "internal humostasis."
System involvement in diseases
The best example of the important part of the endocannabinoid system in the homeostasis process is From studies conducted in recent years And showed unusual involvement and activity of cannabinoid receptors in cancer cells in a variety of different cancers, including lung cancer, liver cancer, breast cancer and prostate cancer.
The same studies found that cannabinoids can kill cancer cells, including those found to be resistant to chemotherapy, as well as prevent cancer cells from developing in advance. Experts believe that the abnormal activity of cannabinoid receptors is a clear indication of the importance of the endocannabinoid system as a biological defense system, as well as the need for cannabis as a health treatment.
Of course, besides the treatment of cancer, the endocannabinoid system is also important in treating a wide variety of diseases and various health conditions, such as HIV, Alzheimer's, arthritis, cancer, chronic pain, epilepsy, fibromyalgia, glaucoma, MS), sleep problems, post-traumatic stress disorder (PTSD), and more.
In recent years, the highest authorities have also acknowledged the endocrine potential of the endocannabinoid system, including statements by the American Health Organization, the US Drug Enforcement Administration and the US Government Cancer Association, all of which have declared that cannabis has exceptional health properties and can even kill such cancer cells .